What your vet will not tell you about Heartworm

Heartworm has only become a veterinary emergency since pharmaceutical companies have developed expensive treatments and preventatives.  In the past, and even today, dogs can live 8 - 10 years with heartworms.  In the early stages they are completely non life threatening.  In the later stages, sometimes aggressive treatment is warranted.  Regardless of the stage of infection, they do damage the pulmonary arteries and weaken the heart.  The dog needs to receive some kind of treatment.  I will discuss the options below.

Conventional Heartworm Treatment

There is only one treatment available that kills heartworms quickly.  The drug used is called Immiticide.  This drug is injected deeply into the muscle tissue of the back on either side of the spine.  It causes incredible pain to the dog and the injection sites cannot be touched for weeks.  Following injection the dog must remain crated for up to 8 weeks to avoid Pulmonary embolism.  An embolism is a blood clot.  As the heartworms die, the body breaks them down and transports them, via the bloodstream, out of the body.  When using immiticide, the massive die off of worms and then the body's need to clear them out increases the risk of embolism.  Although this treatment is very effective, it is incredibly hard on the dogs and some do die.  They die from not only emboli but also from  reactions to the drug itself.  Add to that the cost of the treatment, and somehow this just does not make sense sometimes.

How Much Does Immiticide Treatment Cost?

That is the $20,000 question of the hour.  It all depends upon how much money your vet wants to make.  My vet charges me $2.50 per pound of body weight, so for a 100 lb dog the cost would be $250.  Not so bad you say?  Well, some vets charge four times that much or more.  If you go to two different vets in the same town, the cost will vary hugely.  Some will require that you have all sorts of blood work and x-rays prior to treatment and some will not.  My vet said he normally does not do these test simply because they will only tell him that the dog has heartworms and needs treatment.  So what is the point?  Vets are getting rich off of heartworm treatment.  They scare people to death and convince them their dog is going to keel over if not treated for $1000 immediately.  This is so unfair to poor pet owners who do not know any better.  They become terrified for the pet they love and vets take advantage of this fear and extort money from them.

Not So Conventional Heartworm Treatment 

As a rescuer, even at a reduced cost, immiticide is often out of the budget.  After discussing this with my vet, he offered me an alternative.  Not only is it cost effective, it also does very little damage to the dog and has almost no side effects.

This treatment is appropriate for younger dogs or dogs with a low heartworm burden.  Dogs in the advanced stages of disease may need Immiticide treatment.  Discuss this with your vet.

Slow Kill Treatment

There are two ways of going about this.  One is to use a liquid medication twice a month or to use standard Heartguard chewable once a month.  We prefer the liquid.  It is far less expensive, works as well, and is readily available in most farm or feed stores.  The liquid is 1% Injectible Ivermectin.  Ivermectin is the active ingredient in Heartguard.

The protocol is as follows;

1CC of 1% Injectible Ivermectin per 110 lbs of body weight, given Orally every two weeks.  This can also be mixed with food.  To determine how much to give use this formula;

 1 divided by 110 = .009 , the dosage is .009 CC per pound of body weight

Multiply .009 times your dog's current weight

Example:  For a 100 pound dog you would multiply .009 x 100 =.9

This dosage is .9 of a CC, so just under one CC.  The dosage does not have to be exactly accurate.  A little over or under will not harm the dog.  Get as close as you can.

We give this dosage every two weeks, either orally or mixed with food.  If the dog is a very strong heartworm positive we sometimes give a cortisone injection with the first two doses of Ivermectin.  This helps to avoid shock due to massive microfilaria die off.  Ivermectin kills microfilaria (circulating heartworm babies).  When microfilaria die they release toxins into the dog's bloodstream.  The dog can have an allergic reaction to these toxins.  The cortisone helps to keep the danger of this happening to a minimum.

Ivermectin does not kill adult heartworms.  It does weaken them and will speed up their death.  Heartworms typically live two years.  To further speed up the process of heartworm kill we also add a 30 day regimen of Doxycycline.  The Doxycycline kills off an organism within heartworms called wolbachia.  Wolbachia is a symbiotic organism that lives within adult heartworms.  By treating an infested dog with a 30 day regimen of Doxycycline, you kill off the wolbachia, weakening the adult heartworms.  This also is reported to lessen the inflammatory immune response of worm die off when the dog is receiving HW treatment of any kind.   By weakening the heartworms and then continuing to treat with Ivermectin, you can clear a dog of heartworms typically in 18 months or less.

We do a bi weekly dosage of Ivermectin for six months and then go to a once monthly dosage for life.  The liquid Ivermectin will act as a monthly preventative also.

Wolbachia

Since this information is relatively new, you may want to reference the following articles or print them down for your vet.

From what I can tell, giving Doxycycline to dogs to help eliminate the Wolbachia bacteria that live symbiotically in the
heartworms weakens the adult worms and helps destroy the microfilaria that they produce, as well as reducing the potential for the worms to cause damage due to inflammation, embolism and allergic reaction. It appears to be most effective if given prior to heartworm treatment, but may also have some effect if given during heartworm treatment (including slow-kill treatment with monthly Heartguard or bi weekly Ivermectin). Here is some additional info on the topic that I was able to find, though most of it is highly technical and still in preliminary stages of research:

http://www.veterinarypartner.com/Content.plx?P=A&A=610
"Wolbachia is a genus of rickettsial organisms (sort of like
bacteria, but not exactly). They live inside the adult heartworm.
These organisms seem to be protective or beneficial to heartworms and
treating the dog with the antibiotic doxycycline seems to sterilize
female heartworms (meaning they cannot reproduce). Wolbachia is also
thought to be involved in the embolism and shock that result when
heartworms die. The role of this organism is still being
investigated. If your veterinarian wants to pre-treat your heartworm
positive dog with doxycycline, it may be because of concerns
regarding this organism. As new information emerges, we will post here."
 

http://www.vetmed.auburn.edu/~blagbbl/Blagburnheskasymposium.pdf
"Wolbachia are intracellular bacteria that infect numerous species of
filarial worms including heartworms. Many contend that these friendly
inhabitants (endosymbionts) play a role in the pathogenesis of
diseases caused by heartworms and other filarids. Contention is that
host immune responses directed at Wolbachia can actually go awry and
enhance the disease process in heartworm infections. Some also
contend that elimination of Wolbachia spp. from heartworms may affect
the survival of adult heartworms and may decrease the host's errant
immunologic responses when adult worms are killed or die."

<http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2005&PID=10906&O=Generic>
"Dirofilaria immitis [heartworms] the cause of heartworm disease in
dogs and cats harbors an endosymbiont intracellular bacteria of the
genus Wolbachia (a Rickettsia). Studies performed recently indicate
that these bacteria may play an important role in the pathogenesis
and immune response to filarial infection (Bandi et al, 2001)." This
article goes on to say that Wolbachia may contribute to many of the
side effects of heartworm disease, including inflammation, kidney
disease, lung problems and allergic reactions.

<http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2005&PID=10907&O=Generic>
"Furthermore, preliminary data from our laboratory indicates that
antibiotic treatment before adulticide therapy in dogs with heartworm
disease leads to a decrease in pro-inflammatory cytokines, particularly IL-8."

http://lib.bioinfo.pl/meid:13044
This site has numerous other studies on human treatment, indicating
that doxycycline, oxytetracycline (of which doxycycline is a
derivative) and rifampicin (sometimes use in conjunction with
doxycycline) are all effective against Wolbachia.

I am not a vet. This article is the result of personal experience. Please always confer with your vet to be sure that this treatment is appropriate for your pet. If you have any questions regarding this material please feel free to email me at information@adoptarott.net